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PIN1 a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2-M transition of the cell cycle. Has two distinct functional domains: an N-terminal WW domain and a C-terminal PPlase domain. Pin1 interacts with a series of mitotic phosphoproteins, including Plk1, cdc25C and cdc27, catalyzing pSer-Pro or pThr/Pro cis/trans isomerizations. Displays a preference for an acidic residue n-terminal to the isomerized proline bond. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytosol; midbody; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; GTPase activating protein binding; mitogen-activated protein kinase kinase binding; motor activity; peptidyl-prolyl cis-trans isomerase activity; phosphoserine binding; phosphothreonine binding; protein binding
Biological Process: negative regulation of interferon type I production; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; neuron differentiation; positive regulation of GTPase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ubiquitin-protein ligase activity; protein peptidyl-prolyl isomerization; protein stabilization; regulation of cytokinesis; regulation of mitosis; synapse organization and biogenesis
Reference #:  Q13526 (UniProtKB)
Alt. Names/Synonyms: DOD; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; PIN1; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1; Rotamase Pin1; UBL5
Gene Symbols: PIN1
Molecular weight: 18,243 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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