Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

PTP1B a non-receptor phospho-tyrosine protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation and inactivation of PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. Negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of insulin receptor. Also reported to dephosphorylate integrin, epidermal growth factor receptor, JAK2 and TYK2, regulating cell growth control and the cellular response to interferon. May regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Phosphatase; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: cytosol; early endosome; endoplasmic reticulum; plasma membrane
Molecular Function: cadherin binding; enzyme binding; ephrin receptor binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; RNA binding; zinc ion binding
Biological Process: actin cytoskeleton reorganization; negative regulation of MAP kinase activity; negative regulation of signal transduction; negative regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid dephosphorylation; regulation of endocytosis; regulation of intracellular protein transport; regulation of signal transduction; unfolded protein response; unfolded protein response, activation of signaling protein activity
Disease: Diabetes Mellitus, Noninsulin-dependent
Reference #:  P18031 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 1; protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTN1; PTP-1B; PTP1B; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
Gene Symbols: PTPN1
Molecular weight: 49,967 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene