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MAP2 a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: cytosol; dendrite; microtubule associated complex; neuron projection; nucleolus
Molecular Function: microtubule binding; protein binding
Biological Process: central nervous system neuron development; dendrite morphogenesis; microtubule cytoskeleton organization and biogenesis; neurite development
Reference #:  P11137 (UniProtKB)
Alt. Names/Synonyms: DKFZp686I2148; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Microtubule-associated protein 2
Gene Symbols: MAP2
Molecular weight: 199,526 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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