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Protein Page:
SREBP-1 iso3

SREBP-1 iso3 Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; Golgi membrane; nuclear envelope; nucleoplasm; nucleus
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; sterol response element binding; transcription factor activity
Biological Process: cellular response to starvation; circadian rhythm; lipid biosynthetic process; lipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cholesterol biosynthetic process; regulation of protein stability; regulation of transcription from RNA polymerase II promoter
Reference #:  P36956-3 (UniProtKB)
Alt. Names/Synonyms: BHLHD1; Class D basic helix-loop-helix protein 1; Processed sterol regulatory element-binding protein 1; SRBP1; SREBF1; SREBP-1; SREBP-1c; SREBP1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Gene Symbols: SREBF1
Molecular weight: 111,102 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
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SREBP-1 iso3

Protein Structure Not Found.
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