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BMF May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytoskeletal
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: cytosol; mitochondrial outer membrane; myosin complex; plasma membrane
Molecular Function: protein binding
Biological Process: anoikis; negative regulation of autophagy; positive regulation of apoptosis; positive regulation of protein homooligomerization; protein insertion into mitochondrial membrane during induction of apoptosis
Reference #:  Q96LC9 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-modifying factor; Bcl2 modifying factor; BMF; FLJ00065
Gene Symbols: BMF
Molecular weight: 20,508 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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