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GRB2 an adaptor protein of the GRB2 / sem-5 / DRK family. Associates with many different tyrosine-phosphorylated proteins via its SH2 domain, including EGFR, PDGFR, IRS-1, SHC and LNK. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Four alternatively spliced isoforms have been described. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: cytoplasm; cytosol; endosome; extrinsic to internal side of plasma membrane; nucleolus; nucleoplasm; nucleus; plasma membrane; signalosome
Molecular Function: 1-phosphatidylinositol-3-kinase activity; ephrin receptor binding; epidermal growth factor receptor binding; identical protein binding; insulin receptor substrate binding; neurotrophin TRKA receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine binding; protein binding; protein kinase binding; Ras guanyl-nucleotide exchange factor activity; RNA binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process: axon guidance; cell differentiation; cell migration; cell-cell signaling; DNA damage response, signal transduction; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; negative regulation of epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; Ras protein signal transduction; receptor internalization; regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade; T cell costimulation
Reference #:  P62993 (UniProtKB)
Alt. Names/Synonyms: abundant SRC homology; Adapter protein GRB2; ASH; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; GRB2; Grb3-3; Growth factor receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; NCKAP2; Protein Ash; SH2/SH3 adapter GRB2
Gene Symbols: GRB2
Molecular weight: 25,206 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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