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ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: actin cytoskeleton; cytosol; fibrillar center
Molecular Function: acetyl-CoA carboxylase activity; protein binding
Biological Process: acetyl-CoA metabolic process; acyl-CoA biosynthetic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; positive regulation of cellular metabolic process; protein homotetramerization; regulation of cholesterol biosynthetic process
Disease: Acetyl-coa Carboxylase Deficiency
Reference #:  Q13085 (UniProtKB)
Alt. Names/Synonyms: ACAC; ACACA; ACC; ACC-alpha; ACC1; ACCA; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase-alpha; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Gene Symbols: ACACA
Molecular weight: 265,554 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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