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BID a pro-apoptotic member of the Bcl-2 superfamily. Targets intracellular membranes and contains a BH3 death domain. Heterodimerizes with either the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2, antagonizing its protective effect. The activity of BID is regulated by Caspase 8-mediated cleavage, exposing the BH3 domain and significantly changing the surface charge and hydrophobicity, causing translocation to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced variants have been found. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 6 F1|6 57.02 cM
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion
Molecular Function: protein binding; protein heterodimerization activity; ubiquitin protein ligase binding
Biological Process: apoptotic mitochondrial changes; caspase activation; DNA damage response, signal transduction; organelle ATP synthesis coupled electron transport; positive regulation of apoptosis; positive regulation of protein homooligomerization; positive regulation of protein oligomerization; protein homooligomerization; protein targeting to mitochondrion; regulation of apoptosis; regulation of cell proliferation; regulation of protein oligomerization; release of cytochrome c from mitochondria
Reference #:  P70444 (UniProtKB)
Alt. Names/Synonyms: 2700049M22Rik; AI875481; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; OTTMUSP00000028756; p11 BID; p13 BID; p15 BID; p22 BID
Gene Symbols: Bid
Molecular weight: 21,952 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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