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gp130 gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: cell soma; ciliary neurotrophic factor receptor complex; dendrite; external side of plasma membrane; extracellular exosome; extracellular region; interleukin-6 receptor complex; membrane; oncostatin-M receptor complex; plasma membrane
Molecular Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-27 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein homodimerization activity
Biological Process: ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-11-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-6-mediated signaling pathway; leukemia inhibitory factor signaling pathway; negative regulation of apoptosis; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; regulation of Notch signaling pathway; response to cytokine; viral process
Reference #:  P40189 (UniProtKB)
Alt. Names/Synonyms: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha
Gene Symbols: IL6ST
Molecular weight: 103,537 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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