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SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; protein complex
Molecular Function: 1-phosphatidylinositol-3-kinase activity; cell adhesion molecule binding; D1 dopamine receptor binding; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phospholipase binding; phosphoprotein phosphatase activity; protein binding; protein domain specific binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process: abortive mitotic cell cycle; activation of MAPK activity; axon guidance; Bergmann glial cell differentiation; brain development; cellular response to epidermal growth factor stimulus; cerebellar cortex formation; DNA damage checkpoint; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; ERBB signaling pathway; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling pathway; inner ear development; integrin-mediated signaling pathway; leukocyte migration; microvillus organization; multicellular organism growth; multicellular organismal reproductive process; negative regulation of cell adhesion mediated by integrin; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; nerve growth factor receptor signaling pathway; organ growth; phosphatidylinositol phosphorylation; platelet activation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of glucose import in response to insulin stimulus; positive regulation of hormone secretion; positive regulation of mitotic cell cycle; positive regulation of protein kinase B signaling; regulation of cell adhesion mediated by integrin; regulation of multicellular organism growth; regulation of protein complex assembly; regulation of protein export from nucleus; T cell costimulation; triacylglycerol metabolic process
Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1
Reference #:  Q06124 (UniProtKB)
Alt. Names/Synonyms: BPTP3; CFC; MGC14433; NS1; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase-2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP-2; Shp2; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11
Gene Symbols: PTPN11
Molecular weight: 68,436 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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