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RAD51 a member of the RAD51 protein family. Involved in the homologous recombination and repair of DNA. Interacts with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. Interacts with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both its intracellular localization and DNA-binding ability. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Defects in RAD51 are associated with breast cancer. Two alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Mitochondrial
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: chromatin; condensed chromosome; condensed nuclear chromosome; cytoplasm; cytosol; lateral element; mitochondrion; nuclear chromatin; nuclear chromosome; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body
Molecular Function: ATP binding; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; identical protein binding; protein binding; protein C-terminus binding; recombinase activity; single-stranded DNA binding; single-stranded DNA-dependent ATPase activity
Biological Process: DNA recombinase assembly; DNA recombination; DNA repair; DNA synthesis during DNA repair; DNA unwinding during replication; double-strand break repair via homologous recombination; meiotic cell cycle; meiotic recombination; mitotic recombination; positive regulation of DNA ligation; protein homooligomerization; replication fork processing; response to DNA damage stimulus; strand displacement; strand invasion; telomere maintenance via recombination
Disease: Breast Cancer; Fanconi Anemia, Complementation Group R; Mirror Movements 2
Reference #:  Q06609 (UniProtKB)
Alt. Names/Synonyms: BRCA1/BRCA2-containing complex, subunit 5; BRCC5; DNA repair protein RAD51 homolog 1; hRAD51; HsRAD51; HsT16930; RAD51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog A; RAD51 homolog protein; RAD51A; RECA; RecA, E. coli, homolog of; RecA-like protein; recombination protein A
Gene Symbols: RAD51
Molecular weight: 36,966 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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