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NMDAR2A a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component: cell surface; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane
Molecular Function: protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: glutamate signaling pathway; learning and/or memory; MAPKKK cascade; response to ethanol; synaptic transmission; transport
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Reference #:  Q12879 (UniProtKB)
Alt. Names/Synonyms: Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; GRIN2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; NMDAR2A; NMDE1; NR2A
Gene Symbols: GRIN2A
Molecular weight: 165,283 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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