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Protein Page:

STAT5B transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: chromatin binding; glucocorticoid receptor binding; protein binding; protein dimerization activity; protein-tyrosine kinase activity; transcription factor activity
Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; cellular response to hormone stimulus; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; isoleucine metabolic process; JAK-STAT cascade; oxaloacetate metabolic process; positive regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; succinate metabolic process; taurine metabolic process; valine metabolic process
Disease: Growth Hormone Insensitivity With Immunodeficiency
Reference #:  P51692 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B
Gene Symbols: STAT5B
Molecular weight: 89,866 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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