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TSC2 a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; TSC1-TSC2 complex
Molecular Function: GTPase activator activity; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding
Biological Process: anoikis; cell cycle arrest; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of Wnt receptor signaling pathway; neural tube closure; positive chemotaxis; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling cascade; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; vesicle-mediated transport
Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 2
Reference #:  P49815 (UniProtKB)
Alt. Names/Synonyms: FLJ43106; LAM; TSC2; TSC4; Tuberin; tuberous sclerosis 2; Tuberous sclerosis 2 protein
Gene Symbols: TSC2
Molecular weight: 200,608 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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