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GRB10 an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p12.1
Cellular Component: cytoplasm; cytosol; plasma membrane; protein complex
Molecular Function: insulin receptor binding; protein binding
Biological Process: axon guidance; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; positive regulation of vascular endothelial growth factor receptor signaling pathway
Reference #:  Q13322 (UniProtKB)
Alt. Names/Synonyms: Grb-10; GRB-IR; GRB10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; MEG1; RSS
Gene Symbols: GRB10
Molecular weight: 67,231 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
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