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S100A1 Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Belongs to the S-100 family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: extracellular region; nucleus; sarcoplasmic reticulum
Molecular Function: ATPase binding; identical protein binding; protein binding; protein homodimerization activity
Biological Process: substantia nigra development; toll-like receptor signaling pathway
Reference #:  P23297 (UniProtKB)
Alt. Names/Synonyms: Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100; S100 alpha; S100 calcium binding protein A1; S100 calcium-binding protein A1; S100 protein, alpha polypeptide; S100-alpha; S100A; S100A1; S10A1
Gene Symbols: S100A1
Molecular weight: 10,546 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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