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RAPGEF4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 2|2 C3
Cellular Component: apical plasma membrane; axon; basolateral plasma membrane; brush border; cell soma; cilium; cytosol; dendrite; dendritic spine; excitatory synapse; growth cone; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; protein complex
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: calcium ion-dependent exocytosis; cAMP-mediated signaling; insulin secretion; negative regulation of synaptic transmission; positive regulation of protein secretion; positive regulation of smooth muscle cell migration; regulation of dendrite development; regulation of exocytosis; signal transduction
Reference #:  Q9EQZ6 (UniProtKB)
Alt. Names/Synonyms: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; Cgef2; EPAC 2; Epac2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; KIAA4040; mKIAA4040; OTTMUSP00000014141; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; Rapgef4; RPGF4
Gene Symbols: Rapgef4
Molecular weight: 115,491 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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