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Protein Page:

CRKL an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; endosome
Molecular Function: cadherin binding; phosphotyrosine binding; protein binding; RNA binding; SH3/SH2 adaptor activity; signal transducer activity
Biological Process: activation of MAPKK activity; JNK cascade; positive regulation of cell proliferation; Ras protein signal transduction
Reference #:  P46109 (UniProtKB)
Alt. Names/Synonyms: Crk-like protein; CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Gene Symbols: CRKL
Molecular weight: 33,777 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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