Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CRK an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; cytosol; nucleus; protein complex
Molecular Function: ephrin receptor binding; phosphotyrosine binding; protein binding; protein phosphorylated amino acid binding; protein self-association; SH2 domain binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process: activation of MAPKK activity; ephrin receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of GTPase activity; regulation of protein binding; regulation of signal transduction; regulation of transcription from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway
Reference #:  P46108 (UniProtKB)
Alt. Names/Synonyms: Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
Gene Symbols: CRK
Molecular weight: 33,831 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein