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KIF3A Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Heterodimer of KIF3A and KIF3B. Interacts with PIFO/C1orf88. Interacts with CLN3. Belongs to the kinesin-like protein family. Kinesin II subfamily. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: centriole; centrosome; cilium; cytosol; kinesin II complex; microtubule cytoskeleton; spindle microtubule
Molecular Function: plus-end-directed microtubule motor activity; protein binding; Rab GTPase binding; spectrin binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; centriole-centriole cohesion; microtubule-based movement; neurogenesis; organelle organization and biogenesis; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q9Y496 (UniProtKB)
Alt. Names/Synonyms: KIF3; KIF3A; kinesin family member 3A; kinesin family protein 3A; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A
Gene Symbols: KIF3A
Molecular weight: 80,041 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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