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SLC20A1 Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: inorganic phosphate transmembrane transporter activity; receptor activity; signal transducer activity; sodium-dependent phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; sodium:phosphate symporter activity
Biological Process: ion transport; phosphate metabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; transport
Reference #:  Q8WUM9 (UniProtKB)
Alt. Names/Synonyms: DKFZp686J2397; FLJ41426; Gibbon ape leukemia virus receptor 1; GLVR-1; GLVR1; Leukemia virus receptor 1 homolog; Phosphate transporter 1; PiT-1; PIT1; S20A1; SLC20A1; Sodium-dependent phosphate transporter 1; solute carrier family 20 (phosphate transporter), member 1; Solute carrier family 20 member 1
Gene Symbols: SLC20A1
Molecular weight: 73,700 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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