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CTNNA2 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Interacts with ZNF639. Belongs to the vinculin/alpha-catenin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: adherens junction; axon; cytoplasm; cytosol
Molecular Function: cadherin binding; protein binding
Biological Process: axonogenesis; brain morphogenesis; cell-cell adhesion; dendrite morphogenesis; positive regulation of muscle cell differentiation; prepulse inhibition; radial glia guided migration of Purkinje cell; regulation of synapse structural plasticity
Reference #:  P26232 (UniProtKB)
Alt. Names/Synonyms: Alpha N-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin-associated protein, related; CAP-R; CAPR; catenin (cadherin-associated protein), alpha 2; Catenin alpha-2; CT 114; CTNA2; CTNNA2; CTNR; DKFZp686H02198
Gene Symbols: CTNNA2
Molecular weight: 105,313 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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