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PLXNA2 Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2. Interacts with RND1. Detected in fetal brain. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; semaphorin receptor activity
Biological Process: branchiomotor neuron axon guidance; regulation of axon extension involved in axon guidance; regulation of cell migration
Reference #:  O75051 (UniProtKB)
Alt. Names/Synonyms: FLJ11751; FLJ30634; KIAA0463; OCT; plexin 2; plexin A2; Plexin-A2; PLXA2; PLXN2; PLXNA2; Semaphorin receptor OCT; transmembrane protein OCT
Gene Symbols: PLXNA2
Molecular weight: 211,104 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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