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VAV1 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: cytosol; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine binding; protein binding; Rho guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: phosphoinositide-mediated signaling; platelet activation; positive regulation of apoptosis; regulation of cell size; regulation of GTPase activity; regulation of phosphoinositide 3-kinase cascade; regulation of small GTPase mediated signal transduction; T cell costimulation; vascular endothelial growth factor receptor signaling pathway
Reference #:  P15498 (UniProtKB)
Alt. Names/Synonyms: oncogene vav; Proto-oncogene vav; VAV; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav proto-oncogene; VAV1
Gene Symbols: VAV1
Molecular weight: 98,314 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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