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TH an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; internal side of plasma membrane; melanosome membrane; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum
Molecular Function: enzyme binding; protein binding; tyrosine 3-monooxygenase activity
Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; dopamine biosynthetic process; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; heart development; learning; locomotory behavior; memory; norepinephrine biosynthetic process; organ morphogenesis; pigmentation; regulation of heart contraction; response to ethanol; response to hypoxia; synaptic transmission, dopaminergic; visual perception
Disease: Segawa Syndrome, Autosomal Recessive
Reference #:  P07101 (UniProtKB)
Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; HTH-2; TH; TH2; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: TH
Molecular weight: 58,600 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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