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TRF1 a telomeric repeat binding factor. Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Involved in the regulation of the mitotic spindle. Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component: fibrillar center; nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus
Molecular Function: DNA bending activity; double-stranded telomeric DNA binding; protein binding; protein homodimerization activity; telomerase activity; telomeric DNA binding; ubiquitin binding
Biological Process: negative regulation of DNA replication; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; telomere capping; telomere maintenance; telomere maintenance via telomerase; telomeric loop formation
Reference #:  P54274 (UniProtKB)
Alt. Names/Synonyms: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1
Gene Symbols: TERF1
Molecular weight: 50,246 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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