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ACSS2 Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; Ligase
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; mitochondrial matrix; nucleoplasm
Molecular Function: acetate-CoA ligase activity; AMP binding
Biological Process: ethanol oxidation; lipid biosynthetic process; mitochondrion organization and biogenesis
Reference #:  Q9NR19 (UniProtKB)
Alt. Names/Synonyms: ACAS2; AceCS; acetate thiokinase; Acetate--CoA ligase; acetate-CoA ligase; Acetyl-CoA synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming); Acetyl-coenzyme A synthetase, cytoplasmic; ACS; ACSA; ACSS2; Acyl-activating enzyme; Acyl-CoA synthetase short-chain family member 2; cytoplasmic acetyl-coenzyme A synthetase; dJ1161H23.1; DKFZp762G026
Gene Symbols: ACSS2
Molecular weight: 78,580 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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