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SNCA a member of the synuclein family that is abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Aggregated forms of the protein are implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Three alternatively spliced human isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: actin cytoskeleton; axon; cell cortex; cytoplasm; cytosol; extracellular region; extracellular space; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane
Molecular Function: alpha-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; fatty acid binding; ferrous iron binding; histone binding; Hsp70 protein binding; identical protein binding; kinesin binding; magnesium ion binding; oxidoreductase activity; phospholipid binding; phosphoprotein binding; protein binding; tau protein binding; zinc ion binding
Biological Process: calcium ion homeostasis; caspase activation; cellular protein metabolic process; dopamine biosynthetic process; dopamine uptake; microglial cell activation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of norepinephrine uptake; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of dopamine secretion; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synaptic vesicle endocytosis
Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
Reference #:  P37840 (UniProtKB)
Alt. Names/Synonyms: Alpha-synuclein; alpha-synuclein, isoform NACP140; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein, alpha (non A4 component of amyloid precursor); SYUA
Gene Symbols: SNCA
Molecular weight: 14,460 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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