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Survivin an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: chromosome, pericentric region; cytoplasm; cytosol; midbody; nuclear chromosome; nucleoplasm; nucleus
Molecular Function: chaperone binding; cysteine protease inhibitor activity; enzyme binding; identical protein binding; microtubule binding; protein binding; Ran GTPase binding; ubiquitin-protein ligase activity
Biological Process: negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein amino acid phosphorylation; protein complex localization; protein sumoylation; protein ubiquitination; regulation of apoptosis; regulation of mitotic cell cycle; regulation of signal transduction; sensory perception of sound; sister chromatid cohesion
Reference #:  O15392 (UniProtKB)
Alt. Names/Synonyms: API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha
Gene Symbols: BIRC5
Molecular weight: 16,389 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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