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STF-1 a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription coactivator activity
Biological Process: cell-cell signaling; female gonad development; hormone-mediated signaling; male gonad development; positive regulation of transcription from RNA polymerase II promoter; primary sex determination; regulation of steroid biosynthetic process; sex determination; tissue development; transcription initiation from RNA polymerase II promoter
Disease: 46,xx Sex Reversal 4; 46,xy Sex Reversal 3; Premature Ovarian Failure 7; Spermatogenic Failure 8
Reference #:  Q13285 (UniProtKB)
Alt. Names/Synonyms: AD4BP; adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ1; FTZF1; Fushi tarazu factor homolog 1; NR5A1; nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; POF7; SF-1; SF1; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; steroidogenic factor-1; STF-1; STF1
Gene Symbols: NR5A1
Molecular weight: 51,636 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
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