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STAT5A transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytosol; nucleoplasm
Molecular Function: protein binding; protein-tyrosine kinase activity
Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; isoleucine metabolic process; JAK-STAT cascade; oxaloacetate metabolic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; succinate metabolic process; taurine metabolic process; valine metabolic process
Reference #:  P42229 (UniProtKB)
Alt. Names/Synonyms: MGF; Signal transducer and activator of transcription 5A; STA5A; STAT5; STAT5A
Gene Symbols: STAT5A
Molecular weight: 90,647 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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