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STAT3 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; RNA polymerase II transcription factor complex
Molecular Function: CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; glucocorticoid receptor binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process: acute-phase response; aging; astrocyte differentiation; cell motility; cell proliferation; cellular response to hormone stimulus; cellular response to leptin stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; inflammatory response; interleukin-6-mediated signaling pathway; interleukin-7-mediated signaling pathway; intracellular receptor signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA mediated inhibition of translation; mRNA transcription from RNA polymerase II promoter; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of glycolytic process; negative regulation of hydrogen peroxide biosynthetic process; negative regulation of neuron death; negative regulation of neuron migration; negative regulation of stem cell differentiation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of angiogenesis; positive regulation of ATP biosynthetic process; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of gene silencing by miRNA; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of metalloendopeptidase activity; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial cell proliferation; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to drug; response to estradiol; response to ethanol; response to leptin; sexual reproduction; signal transduction; somatic stem cell maintenance; T-helper 17 cell lineage commitment; thermoregulation; viral process
Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant
Reference #:  P40763 (UniProtKB)
Alt. Names/Synonyms: Acute-phase response factor; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3
Gene Symbols: STAT3
Molecular weight: 88,068 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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