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STAT3 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; plasma membrane
Molecular Function: chromatin DNA binding; DNA binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor activity; transcription factor binding
Biological Process: astrocyte differentiation; cell motility; cellular response to hormone stimulus; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; inflammatory response; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of erythrocyte differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to estradiol stimulus; sexual reproduction; signal transduction; somatic stem cell maintenance; thermoregulation
Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant
Reference #:  P40763 (UniProtKB)
Alt. Names/Synonyms: Acute-phase response factor; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3
Gene Symbols: STAT3
Molecular weight: 88,068 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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