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STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: axon; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: cadherin binding; double-stranded DNA binding; enzyme binding; identical protein binding; nuclear hormone receptor binding; protein binding; protein homodimerization activity; transcription factor activity; tumor necrosis factor receptor binding
Biological Process: apoptosis; blood circulation; endothelial cell migration; JAK-STAT cascade; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of erythrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; response to cAMP; response to cytokine stimulus; response to peptide hormone stimulus; tumor necrosis factor-mediated signaling pathway
Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
Reference #:  P42224 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B04100; ISGF-3; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT1; STAT91; Transcription factor ISGF-3 components p91/p84
Gene Symbols: STAT1
Molecular weight: 87,335 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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