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JARID1B Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; histone binding; histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: regulation of transcription from RNA polymerase II promoter
Reference #:  Q9UGL1 (UniProtKB)
Alt. Names/Synonyms: Cancer/testis antigen 31; CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; Histone demethylase JARID1B; JARID1B; jumonji, AT rich interactive domain 1B; Jumonji/ARID domain-containing protein 1B; KDM5B; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; PLU1; PUT1; putative DNA/chromatin binding motif; RBBP2H1; RBBP2H1A; RBP2-H1; RBP2-like; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
Gene Symbols: KDM5B
Molecular weight: 175,658 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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