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SMAD1 transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q31.21
Cellular Component: cytoplasm; cytosol; nuclear inner membrane; nucleoplasm; nucleus; protein complex
Molecular Function: DEAD/H-box RNA helicase binding; identical protein binding; protein binding; protein kinase binding; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: BMP signaling pathway; embryonic pattern specification; positive regulation of transcription from RNA polymerase II promoter; primary microRNA processing; protein deubiquitination; SMAD protein complex assembly
Reference #:  Q15797 (UniProtKB)
Alt. Names/Synonyms: BSP-1; BSP1; hSMAD1; JV4-1; JV41; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; SMAD 1; SMAD family member 1; SMAD, mothers against DPP homolog 1; SMAD1; TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; Transforming growth factor-beta-signaling protein 1
Gene Symbols: SMAD1
Molecular weight: 52,260 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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