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LLGL1 Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Belongs to the WD repeat L(2)GL family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: axon; cortical actin cytoskeleton; cytoplasm; cytoskeleton; early endosome membrane; Golgi cis cisterna; plasma membrane; trans-Golgi network membrane
Molecular Function: GTPase activator activity; protein binding; protein kinase binding; Rab GTPase binding; structural molecule activity; syntaxin binding
Biological Process: axonogenesis; cortical actin cytoskeleton organization and biogenesis; Golgi to plasma membrane transport; protein complex assembly; regulation of exocytosis; regulation of protein secretion
Reference #:  Q15334 (UniProtKB)
Alt. Names/Synonyms: DLG4; HUGL; Hugl-1; HUGL1; Human homolog to the D-lgl gene protein; L2GL1; lethal giant larvae homolog 1 (Drosophila); Lethal(2) giant larvae protein homolog 1; LLGL; LLGL1
Gene Symbols: LLGL1
Molecular weight: 115,418 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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