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CASP12 Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease
Chromosomal Location of Human Ortholog: 9 A1|9 2.46 cM
Cellular Component: cytosol; endoplasmic reticulum; intracellular membrane-bound organelle; nucleus
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; peptidase activity; protease binding; protein binding
Biological Process: apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; protein autoprocessing; proteolysis; unfolded protein response
Reference #:  O08736 (UniProtKB)
Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; CASPC
Gene Symbols: Casp12
Molecular weight: 47,854 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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