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RHOA a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: apical junction complex; cell cortex; cell junction; cleavage furrow; cytosol; dendritic spine; endoplasmic reticulum membrane; endosome; extrinsic to internal side of plasma membrane; focal adhesion; lamellipodium; plasma membrane; secretory granule membrane; vesicle
Molecular Function: GTP binding; GTPase activity; myosin binding; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; apical junction assembly; cell migration; endothelial cell migration; ephrin receptor signaling pathway; negative chemotaxis; negative regulation of axonogenesis; negative regulation of cell size; neutrophil degranulation; phosphoinositide-mediated signaling; platelet activation; positive regulation of axonogenesis; positive regulation of cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; positive regulation of neuron differentiation; positive regulation of stress fiber formation; protein deubiquitination; regulation of actin cytoskeleton organization and biogenesis; regulation of cell migration; regulation of osteoblast proliferation; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; stress fiber formation; substantia nigra development; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P61586 (UniProtKB)
Alt. Names/Synonyms: Aplysia ras-related homolog 12; ARH12; ARHA; h12; oncogene RHO H12; ras homolog gene family, member A; Rho cDNA clone 12; RHO12; RHOA; RHOH12; small GTP binding protein RhoA; Transforming protein RhoA
Gene Symbols: RHOA
Molecular weight: 21,768 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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