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Radixin a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: apical plasma membrane; cortical actin cytoskeleton; extracellular space; filopodium; focal adhesion; lamellipodium; microvillus; plasma membrane
Molecular Function: actin binding; ATPase binding; cadherin binding; protein binding; protein homodimerization activity; protein kinase A binding; RNA binding
Biological Process: establishment of protein localization; negative regulation of cell size; negative regulation of homotypic cell-cell adhesion; positive regulation of cell migration; regulation of actin filament bundle formation; regulation of cell shape; regulation of cell size; regulation of GTPase activity; regulation of Rap protein signal transduction
Disease: Deafness, Autosomal Recessive 24
Reference #:  P35241 (UniProtKB)
Alt. Names/Synonyms: DFNB24; RADI; Radixin; RDX
Gene Symbols: RDX
Molecular weight: 68,564 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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