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Protein Page:

IFITM3 IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 F5
Cellular Component: apical part of cell; cell surface; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; nucleus; plasma membrane
Biological Process: defense response to virus; negative regulation of cell proliferation; negative regulation of viral genome replication; negative regulation of viral transcription; negative regulation of virion penetration into host cell; receptor-mediated endocytosis; response to virus
Reference #:  Q9CQW9 (UniProtKB)
Alt. Names/Synonyms: 1110004C05Rik; Cd225; Cdw217; Fgls; Fragilis; Ifitm3; Interferon induced transmembrane protein 3; Interferon-inducible protein 15; IP15; MCG22590; mil-1
Gene Symbols: Ifitm3
Molecular weight: 14,954 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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