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PTEN a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; EC; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Phosphatase, lipid; Tumor suppressor
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytosol; internal side of plasma membrane; neuron projection; nucleoplasm; nucleus; plasma membrane
Molecular Function: enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: apoptosis; brain morphogenesis; cell migration; cell proliferation; central nervous system development; central nervous system neuron axonogenesis; dentate gyrus development; forebrain morphogenesis; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; heart development; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; myelin maintenance in the central nervous system; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of focal adhesion formation; negative regulation of keratinocyte migration; negative regulation of organ growth; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of transcription factor activity; prepulse inhibition; protein amino acid dephosphorylation; protein deubiquitination; protein kinase B signaling cascade; protein stabilization; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; T cell receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
Reference #:  P60484 (UniProtKB)
Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1
Gene Symbols: PTEN
Molecular weight: 47,166 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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