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PLXNA1 Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: plasma membrane
Molecular Function: receptor activity; semaphorin receptor activity
Biological Process: branchiomotor neuron axon guidance; multicellular organismal development; regulation of axon extension involved in axon guidance
Reference #:  Q9UIW2 (UniProtKB)
Alt. Names/Synonyms: DKFZp761P19121; NOV; NOVP; plexin 1; plexin A1; Plexin-A1; PLXA1; PLXN1; PLXNA1; Semaphorin receptor NOV
Gene Symbols: PLXNA1
Molecular weight: 211,067 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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