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FLOT2 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECM29. In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. Belongs to the band 7/mec-2 family. Flotillin subfamily. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasmic vesicle; endocytic vesicle; endosome; flotillin complex; focal adhesion; lamellipodium; membrane; perinuclear region of cytoplasm; plasma membrane; uropod; vesicle
Molecular Function: protein binding; protein heterodimerization activity
Biological Process: epidermis development; lipid raft formation; protein stabilization; regulation of heterotypic cell-cell adhesion; regulation of myoblast differentiation; regulation of toll-like receptor 3 signaling pathway
Reference #:  Q14254 (UniProtKB)
Alt. Names/Synonyms: ECS-1; ECS1; Epidermal surface antigen; ESA; ESA1; FLOT2; flotillin 2; Flotillin 2 (epidermal surface antigen 1); Flotillin-2; M17S1; Membrane component chromosome 17 surface marker 1; membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
Gene Symbols: FLOT2
Molecular weight: 47,064 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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