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PLCB3 a phosphatidylinositol-specific phospholipase C. Binds to calmodulin. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Phospholipase
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: cytosol; nucleoplasm; protein complex
Molecular Function: cadherin binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: inositol phosphate metabolic process; regulation of systemic arterial blood pressure; Wnt receptor signaling pathway, calcium modulating pathway
Reference #:  Q01970 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; FLJ37084; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-3; phospholipase C beta 3; phospholipase C, beta 3 (phosphatidylinositol-specific); Phospholipase C-beta-3; PLC beta 3; PLC-beta-3; PLCB3
Gene Symbols: PLCB3
Molecular weight: 138,799 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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