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ATG5 Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: autophagic vacuole; axoneme; cytoplasm; cytosol; membrane; phagocytic vesicle membrane; pre-autophagosomal structure membrane
Molecular Function: APG8 conjugating enzyme activity; protein binding
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; cellular response to nitrogen starvation; macroautophagy; mitochondrion degradation; post-translational protein modification
Disease: Spinocerebellar Ataxia, Autosomal Recessive 25
Reference #:  Q9H1Y0 (UniProtKB)
Alt. Names/Synonyms: APG5; APG5 (autophagy 5, S. cerevisiae)-like; APG5 autophagy 5-like; APG5-like; APG5L; apoptosis specific protein; Apoptosis-specific protein; ATG5; ATG5 autophagy related 5 homolog (S. cerevisiae); ATG5 autophagy related 5-like; Autophagy protein 5; hAPG5
Gene Symbols: ATG5
Molecular weight: 32,447 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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