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EGF EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hormone; Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: clathrin coated vesicle membrane; extracellular region; extracellular space; lysosomal membrane; plasma membrane; receptor complex
Molecular Function: epidermal growth factor receptor binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine kinase activator activity; Wnt receptor activity; Wnt-protein binding
Biological Process: angiogenesis; DNA replication; embryonic retina morphogenesis in camera-type eye; epidermal growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of secretion; phosphoinositide-mediated signaling; platelet degranulation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor activity; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphorylation; positive regulation of receptor internalization; positive regulation of transcription, DNA-dependent; regulation of phosphoinositide 3-kinase cascade; signal transduction; STAT protein nuclear translocation; Wnt receptor signaling pathway through beta-catenin
Disease: Hypomagnesemia 4, Renal
Reference #:  P01133 (UniProtKB)
Alt. Names/Synonyms: beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); HOMG4; Pro-epidermal growth factor; URG; Urogastrone
Gene Symbols: EGF
Molecular weight: 133,994 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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