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RAB8A May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO/C1orf88. Interacts with BIRC6/bruce. Interacts with OCRL. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: centrosome; cilium; cytosol; extracellular matrix; Golgi membrane; phagocytic vesicle; plasma membrane; recycling endosome membrane; secretory granule membrane; synaptic vesicle; trans-Golgi network membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; Rab GTPase binding
Biological Process: axonogenesis; cellular response to insulin stimulus; G2/M transition of mitotic cell cycle; Golgi vesicle fusion to target membrane; post-translational protein modification; protein secretion; regulation of autophagy; regulation of exocytosis; vesicle docking during exocytosis
Reference #:  P61006 (UniProtKB)
Alt. Names/Synonyms: MEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; RAB8; RAB8A; RAB8A, member RAS oncogene family; ras-associated protein RAB8; Ras-related protein Rab-8A
Gene Symbols: RAB8A
Molecular weight: 23,668 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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