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TNFSF12 Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: extracellular region; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding; receptor binding
Biological Process: apoptosis; endothelial cell migration; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of protein catabolic process; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  O43508 (UniProtKB)
Alt. Names/Synonyms: APO3 ligand; APO3/DR3 ligand; APO3L; DR3LG; MGC129581; MGC20669; TNF-related weak inducer of apoptosis; TNF12; TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; Tumor necrosis factor ligand superfamily member 12; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form; TWEAK
Gene Symbols: TNFSF12
Molecular weight: 27,216 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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