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PARVA Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p15.3
Cellular Component: cytosol; focal adhesion
Molecular Function: cadherin binding; protein binding
Biological Process: establishment and/or maintenance of cell polarity; heterotypic cell-cell adhesion; sprouting angiogenesis
Reference #:  Q9NVD7 (UniProtKB)
Alt. Names/Synonyms: Actopaxin; Alpha-parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha
Gene Symbols: PARVA
Molecular weight: 42,244 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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