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EIF4E2 Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners. EIF4E2 interacts with EIF4EBP1, EIF4EBP2 and EIF4EBP3 but not with eIF4G. Belongs to the eukaryotic initiation factor 4E family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol; mRNA cap complex
Molecular Function: protein binding; RNA binding; RNA cap binding; translation factor activity, nucleic acid binding; ubiquitin protein ligase binding
Biological Process: negative regulation of translation
Reference #:  O60573 (UniProtKB)
Alt. Names/Synonyms: 4E-LP; 4EHP; eIF-4E type 2; eIF4E type 2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; EIF4E2; EIF4EL3; eukaryotic translation initiation factor 4E family member 2; Eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; IF4e; IF4E2; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3
Gene Symbols: EIF4E2
Molecular weight: 28,362 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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